Table 4.
Logistic regression of risk factors of refractory AOSD.
| Parameter† | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| OR (95%CI) | p-value | OR (95%CI) | p-value | |
| Fever | 4.35 (1.91, 9.93) | <0.001 | ||
| Skin rash | 3.43 (1.28, 9.21) | 0.015 | 5.66 (1.06, 30.11) | 0.042 |
| Arthritis | 2.44 (1.13, 5.27) | 0.033 | ||
| Splenomegaly | 5.00 (2.34, 10.68) | <0.001 | 5.27 (1.77, 15.67) | 0.003 |
| Hepatomegaly | 9.55 (2.04, 44.69) | 0.001 | ||
| Pleuritis | 4.02 (1.91, 8.46) | <0.001 | ||
| Pneumonia | 2.65 (1.22, 5.77) | 0.019 | ||
| Ferritin ≥ 3,427 (ng/mL) | 4.58 (1.95, 10.73) | <0.001 | ||
| ESR ≥ 69 (mm/h) | 3.31 (1.54, 7.13) | 0.002 | 6.95 (2.17, 22.21) | 0.001 |
| CRP ≥ 127.5 (mg/L) | 3.05 (1.24, 7.51) | 0.015 | ||
| N% ≥ 86.3% | 2.70 (1.15, 6.34) | 0.032 | ||
| Hb ≤ 109.5 (g/L) | 3.40 (1.62, 7.12) | 0.001 | ||
| LDH ≥ 450 (IU/L) | 3.80 (1.77, 8.17) | 0.001 | ||
| ALT ≥ 87 (IU/L) | 4.88 (2.20, 10.82) | <0.001 | ||
| AST ≥ 111 (IU/L) | 6.00 (2.43, 14.84) | <0.001 | ||
| ALP ≥ 141 (IU/L) | 8.27 (3.53, 19.38) | <0.001 | 5.48 (1.40, 21.55) | 0.015 |
| GGT ≥ 132 (IU/L) | 8.00 (3.24, 19.73) | <0.001 | 5.13 (1.30, 20.22) | 0.020 |
| PreAlb ≤ 163 (mg/L) | 2.50 (1.13, 5.55) | 0.034 | ||
| Alb ≤ 31.5 (g/L) | 2.96 (1.37, 6.42) | 0.006 | ||
| PT ≥ 13.55 (s) | 3.50 (1.43, 8.58) | 0.005 | ||
†
ROC analyses were applied to determine values at the maximum Youden index as cut-off points for continuous variables. Data are presented as OR (95%CI). A p < 0.05 is shown in bold type. ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; N%, the percentage of neutrophils; Hb, hemoglobin; LDH, lactate dehydrogenase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALP, alkaline phosphatase; GGT, gamma-glutamyl transpeptidase; preAlb, prealbumin; Alb, albumin; PT, prothrombin time; OR, odds ratio; CI, confidence interval.