Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The caspase-2 PIDDosome. The PIDDosome is the best characterized caspase-2 activation platform. PIDD-CC and RAIDD form the scaffold for complex formation via an interaction between their corresponding death domains (DD, blue squares). The CARD of caspase-2 binds the CARD of RAIDD (orange squares), promoting proximity-induced dimerization of caspase-2 monomers. This allows caspase-2 to become fully catalytically active.
