TABLE 1.

Caspase-2 substrates.

Substrate	Caspase-2 cleavage motif (human)	Position (human)	Conserved in mouse (Y/N)	Mouse cleavage motif	Position (mouse)	Cleaved by other caspases?
MDM2	DVPD	362	Yes	DVPD	359	Caspase-3
Golgin-160	ESPD	59	Yes	GSPD	59	No
Golgin-160	SEVD	311	Yes	SEAD	308	Caspase-3 and caspase-7
Bid	LQTD	60	Yes	LQTD	59	Caspase-8 and caspase-3
Ku80	GDVD	726	Yes	GDVD	725	Unknown
ICAD	?	?	?	?	?	Caspase-3
Rictor	?	?	?	?	?	Unknown
eIF4B	DRKD	563	Yes	DRKD	563	Caspase-3*
HDAC4	DVTD	289	Yes	DVTD	288	Caspase-3 and caspase-7
Tau	KPVD	314	Yes	KEQD	289	Unknown
HTT	NGKD	213	Yes	NGKD	212	Caspase-3
S1P	LYGD	846	Yes	LYGD	846	Unknown

*With a much lower efficiency than caspase-2.