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. 2020 Dec 23;11:617492. doi: 10.3389/fphys.2020.617492

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Copyright © 2020 Langenbacher, Shimizu, Hsu, Zhao, Borges, Koehler and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transmission electron microscopy analysis of MCU mutant ventricles. Representative TEM images of WT (A–C) and MCU (D–F) ventricular cardiomyocytes. (A,D) WT sarcomeres display clear Z-lines (arrows in A) separated by parallel bands of myosin thick filaments. MCU Z-lines are less well defined and patchy (arrows in D) and thick filaments are sometimes disorganized. (B,C) WT myofibrils are closely associated with oval-shaped mitochondria containing tightly packed cristae (arrowheads in B mark examples, C shows more examples). (E,F) MCU myofibrils are also closely associated with mitochondria, but they are less electron-dense and display a round and swollen morphology with more loosely packed cristae [arrowheads in (E) mark examples, (F) shows more examples]. Scale bars indicate 500 nm.