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. 2020 Dec 23;11:617492. doi: 10.3389/fphys.2020.617492

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Copyright © 2020 Langenbacher, Shimizu, Hsu, Zhao, Borges, Koehler and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis on cardiac arrhythmia in MCU mutant. (A) Increased heartbeat variability in MCU mutants displayed via Poincaré plots of consecutively occurring P-P intervals in adult wildtype and MCU mutant fish. (B) Summary of ECG data from 14 wildtype fish and 14 MCU mutant fish. Different cut-offs of P-P intervals were used to classify severity and definitive of occurring sinoatrial block episodes. Increased sample percentage with SA block episodes, per minute frequency, and consecutively occurring episodes were identified in MCU mutant (compared to wildtype), and further emphasized in MCU Class II mutants.