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. 2020 Dec 23;11:617492. doi: 10.3389/fphys.2020.617492

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Copyright © 2020 Langenbacher, Shimizu, Hsu, Zhao, Borges, Koehler and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RNA-seq analysis of the MCU mutant adult heart. (A) Volcano plot of differential gene expression of MCU mutant hearts vs. wildtype. Each point represents the average value of one transcript in duplicate experiments. The expression difference is considered significant for an adjusted p-value (FDR) of less than 0.05. Red points represent genes significantly upregulated in MCU mutants and blue points represent significantly down regulated genes. FDR, false-discovery rate. (B–D) Selected lists of significantly differentially expressed (FDR < 0.05) ion transporter-encoding (B), structural protein-encoding (C), and mitochondrial protein-encoding (D) genes. The percent increase (+, red) or decrease (-, blue) in expression in MCU compared to WT, based on the fold-changes determined by Cufflinks, is displayed in the right column.