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. 2020 Dec 23;11:617492. doi: 10.3389/fphys.2020.617492

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Copyright © 2020 Langenbacher, Shimizu, Hsu, Zhao, Borges, Koehler and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Downregulated genes in MCU hearts suggest defects in cardiac structure and function. (A,B) Dot plots of over-represented Biological Process (A) and Molecular Function (B) gene ontology terms in the set of genes that is significantly downregulated in MCU mutant hearts. The dot size indicates the number of genes associated with each term and the dot color indicates the significance of the enrichment (adjusted p-values). (C) Gene concept networks of the top 10 over-represented Biological Process gene ontology terms in the set of genes that is significantly downregulated in MCU mutants. The dot size indicates the number of genes associated with each term and dots representing genes are colored based on their fold-change [log2(fold-change)].