Table 1.
STIM target molecules.
| Interacting protein | Identity of binding protein | Subcellular location | Function | STIM isoform |
|---|---|---|---|---|
| Orai | Ca2+ channel | PM | Positive effector | STIM1 STIM2 |
| TRP | Ca2+ channel | PM | Positive effector | STIM1 |
| VGCC | Ca2+ channel | PM | Negative effector | STIM1 |
| AMPAR | Ionotropic receptor | PM | Positive effector | STIM1 STIM2 |
| NMDAR | Ionotropic receptor | PM | Negative effector | STIM1 STIM2 |
| mGluR1 | Metabotropic receptor | PM | Positive regulator | STIM1 |
| septin | GTPase | PM lipids (cytoskeleton) | Positive/negative regulator | dSTIM |
| Homer | Scaffolding protein | PSD (cytoskeleton) | Negative regulator | STIM1 |
| SP | Actin-binding protein | PSD (cytoskeleton) | Positive regulator | STIM1 |
| CaMKII | Kinase | PSD (cytoskeleton) | Positive effector | STIM2 |
| EB1, EB3 | Microtubule-binding protein | Cytoplasm (cytoskeleton) | Positive effector/regulator | STIM1 STIM2 |
| Golli proteins | Myelin basic protein | Cytoplasm | Positive regulator | STIM1 |
| SARAF | Transmembrane regulatory factor | ER (predominant), PM | Negative regulator | STIM1 |
| POST | Transmembrane protein | ER (predominant), PM | Positive regulator | STIM1 |
| SERCA | Ca2+-ATPase | ER | Positive effector | STIM1 |
| IP3R | Ca2+ channel | ER | Positive regulator/effector |
dSTIM STIM1 |
| PS1 | Ca2+-leak channel, endoprotease |
ER | Negative regulator | STIM1 STIM2 |
| NEUROD2 | Transcription factor | Nucleus | Negative regulator | STIM1 |
| Sp4 | Transcription factor | Nucleus | Negative effector | STIM1 |
| MG-132/LA | Proteasome inhibitors | Cytoplasm/ nucleus |
Negative regulator | STIM1 STIM2 |
PM, plasma membrane; ER, endoplasmic reticulum; PSD, post-synaptic density.