Fig. 2.

Hypertrophic and Fibrosis gene markers in ATF3-cKO mice. mRNA was extracted from ventricles and the expression levels were measured by qRT-PCR normalized with HSP90 as housekeeping gene. A. Hypertrophic gene markers ANP, BNP and Acta1. B. Fibrosis gene markers Col1α1, Col3α1, TGFβ3, Acta2, CTGF were analyzed. Expression levels are presented as relative values (compared to ATF3-Flox control mice, defined as 1). All results represent the mean ± SE *** P ≤ 0.05, control vs. TAC; †P ≤ 0.05, difference between genotypes. Each dot or triangle represents one mouse. n.s. indicates no statistical difference.