Fig. 4.

Hypertrophic and Fibrosis gene markers in ATF3-fKO mice. mRNA was extracted from ventricles and the expression level were measured by qRT-PCR. A. Hypertrophic gene markers ANP, BNP and Acta1 B. Fibrosis gene markers Col1α1, Col3α1, TGFβ3, Acta2, CTGF were analyzed. Expression levels are presented as relative values (compared to ATF3-Flox control mice, defined as 1). All results represent the mean ± SE *** P ≤ 0.05, control vs. TAC; †P ≤ 0.05, difference between genotypes. Each dot or triangle represents one mouse. n.s. indicates no statistical difference.