Table 6.
Altered amygdala rs-fc with hypothesized regions beyond the prefrontal cortex.
| Model and regressor | Seed | Center of gravity AAL label (notes on location) | BA | Comm | Surface area (mm2) | Mean Z | x | y | z |
|---|---|---|---|---|---|---|---|---|---|
| Posterior cingulate cortex/precuneus | |||||||||
| Dimensional: Abuse | R | L precuneus | CO | 32.7 | −3.59 | −16 | −45 | 45 | |
| R | R median cingulate and paracingulate gyri (PCC) | CO | 58.9 | −3.67 | 7 | −5 | 41 | ||
| L | L median cingulate and paracingulate gyri (PCC)* | 24 | CO | 33.2 | −3.46 | −2 | −1 | 37 | |
| Dimensional: Neglect | R | L precuneus | 7 | DA | 34.1 | −3.33 | −7 | −63 | 46 |
| Insula | |||||||||
| Dimensional: Neglect | L | L insula (anterior insula)* | CO | 32.5 | −3.39 | −29 | 20 | 10 | |
| Dorsal attention network | |||||||||
| General: Adversity | L | L precentral gyrus**: abuse | DA | 95.5 | −3.54 | −32 | 0 | 57 | |
| R | L inferior temporal gyrus* | DA | 25.6 | 3.56 | −46 | −40 | −17 | ||
| Dimensional: Abuse | L | L precentral gyrus**: adv | 6 | DA | 42.4 | −3.38 | −31 | 0 | 53 |
| R | L precentral gyrus | CO, DA | 71.8 | −3.50 | −50 | 5 | 15 | ||
| Dimensional: Neglect | L | L frontal middle gyrus (dlPFC) | DA | 28 | −3.73 | −43 | 35 | 21 | |
| L | L inferior parietal gyrus (intraparietal sulcus) | DA | 216.4 | −3.47 | −36 | −48 | 37 | ||
| Sensory and somatomotor networks | |||||||||
| General: Adversity | L | R parahippocampal gyrus*; *** | Vis, RT | 39.2 | 3.68 | 33 | −39 | −9 | |
| R | R parahippocampal gyrus*; **: abuse | Vis, RT | 58.9 | 3.65 | 35 | −38 | −11 | ||
| Dimensional: Abuse | R | L inferior occipital cortex | 19 | Vis | 59.3 | 3.33 | −42 | −80 | −7 |
| R | R parahippocampal gyrus*; **: adv | 37 | Vis, RT | 76.9 | 3.61 | 34 | −39 | −11 | |
| R | L frontal lobe, sub-gyral (Central sulcus)* | SMm | 34.7 | −3.52 | −33 | −19 | 40 | ||
| R | L postcentral gyrus | 4 | SMm | 68.3 | −3.51 | −47 | −9 | 49 | |
| R | R precentral gyrus | SMm, CO | 128.4 | −3.62 | 49 | −6 | 48 | ||
| Dimensional: Neglect | R | R lingual gyrus* | Vis | 29.1 | 3.49 | 11 | −70 | −7 | |
| R | R cuneus* | 19 | Vis | 31.4 | 3.32 | 7 | −87 | 32 | |
| R | L cuneus*; **:int | 19 | Vis | 39.3 | 3.29 | −6 | −95 | 20 | |
| Dimensional: Interaction | R | R superior occipital gyrus* | Vis | 30.7 | −3.24 | 11 | −96 | 18 | |
| R | L superior occipital gyrus* | 18 | Vis | 38.7 | −3.29 | −10 | −101 | 12 | |
| R | L cuneus*; **: neglect | 19 | Vis | 41.1 | −3.27 | −5 | −96 | 19 | |
| R | R superior occipital gyrus* | Vis | 89.3 | −3.4168 | 18 | −88 | 21 | ||
| R | R postcentral gyrus* | SMh | 27.2 | −3.25 | 51 | −26 | 54 | ||
| R | R postcentral gyrus* | 40 | SMh | 70.3 | −3.39 | 42 | −32 | 49 | |
Note. *: Cluster is not present when controlling for income as a covariate. **Cluster overlaps with another cluster from the same seed but a different regressor (specified as a superscript). ***Cluster overlaps with a cluster associated with neglect that is just below the 25 mm2 threshold, this finding is therefore not discussed as adversity specific. L: left, R: right; x, y, and z coordinates correspond to the cluster’s center of gravity; BA: Brodmann area, if any, associated with the displayed coordinates; Comm: Gordon communities associated with the cluster, if any; Mean Z: average Z-score associated with the regressor across the spatial extent of the cluster. Key for Gordon communities: CO = Cingulo-opercular, DA = Dorsal attention, RT = Retrosplenial-temporal system, SMh = Somatomotor - hand, SMm = Somatomotor - mouth, Vis = Visual. Cluster reporting is hierarchically organized by hypothesized region, model and regressor, and seed. Reporting is comprehensive for each hypothesized region.