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. 2020 Nov;190(11):2267–2281. doi: 10.1016/j.ajpath.2020.08.002

Figure 1.

Figure 1

Pyruvate kinase M2 (PKM2, alias PKM) expression is enhanced in human fibrotic liver. A: PKM2 mRNA expression in human fibrotic liver tissues at different Scheuer fibrosis stages (GSE84044). B: Serial sections of human normal or fibrotic liver tissues were subjected to hematoxylin-eosin (H&E) staining, Sirius red staining, and immunohistochemistry [α-smooth muscle actin (α-SMA) and PKM2], and representative images are shown. Boxed areas are shown at higher magnification to the right. C: Representative double immunofluorescence images of α-SMA (green) and PKM2 (red) labeling in human normal and fibrotic liver tissues. ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001. Scale bars: 200 μm (B); 50 μm (C).