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. 2021 Jan;191(1):26–39. doi: 10.1016/j.ajpath.2020.09.006

Figure 5.

Figure 5

Alternative pathways in the development of high-grade serous carcinoma (HGSC). A: HGSC arising from an ovarian serous cystadenoma. Top left panel: A low-magnification view showing the wall of the cystadenoma with a focal solid growth of HGSC. Top right panel: Normal-appearing epithelium surrounding the solid tumor. Bottom panel: Histologic features of an HGSC. B: HGSC developing directly on the ovarian surface. Top left panel: A low-magnification view showing the whole ovarian section. Top right panel: The ovarian surface showing adenofibroma where the HGSC arises. Bottom panel: HGSC on the surface of adenofibroma. C: HGSC arising from an enlarged ovarian cortical inclusion cyst. Top panel: A low-magnification view of the inclusion cyst. Bottom panel: Highly atypical cells appearing on the surface of the cyst. Scale bars: 100 μm (A, top right panel and bottom panel; B, bottom panel; C, bottom panel); 1 mm (B, top right panel; C, top panel); 1 cm (A, top left panel; B, top left panel).