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. 2020 Dec 23;10:605097. doi: 10.3389/fonc.2020.605097

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Copyright © 2020 Xu, Zhang, Hua, Yang, Wang and Tang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GSEA for samples with high LCN2 expression and low expression. (A) The enriched gene sets in KEGG collection by the high LCN2 expression sample. (B) The enriched gene sets in KEGG by samples with low LCN2 expression. (C) Enriched gene sets in HALLMARK collection, the immunologic gene sets, by samples of high LCN2 expression. (D) Enriched gene sets in HALLMARK by the low LCN2 expression. Each line representing one particular gene set with unique color, and up-regulated genes located in the left approaching the origin of the coordinates, by contrast the down-regulated lay on the right of x-axis. Only gene sets with NOM p < 0.05 and FDR q < 0.06 were considered significant. And only several leading gene sets were displayed in the plot.