Fig. 1.

ACE2 pathway. ACE2 is > 300 times effective to converts Ang II to Ang 1–7 that for converts Ang I to Ang 1–9, which in the presence of NEP or ACE can converts Ang I and Ang 1–9 to Ang 1–7. ACE2 membrane-anchored protein at the catalytically active ectodomain undergoes shedding by the ADAM17, forming a soluble form of ACE2. ACE angiotensin-converting enzyme, ACE2 angiotensin-converting enzyme 2, Ang angiotensin, NEP neprilysin, PCP prolylcarboxypeptidase, ADAM17 disintegrin and metalloproteinase domain‐containing protein 17, Zn metalloproteinase zinc-binding site