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. 2020 Dec 23;8:593653. doi: 10.3389/fcell.2020.593653

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Copyright © 2020 Liu, Zhang, Li and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PECAM1 and CXCR4 are highly expressed in the inflamed dental pulp tissues. (A) Aberrantly activated signaling pathways in the inflammatory dental pulp tissues predicted by GSVA. (B–C) The interacted proteins with PEACM1 and the highly correlated genes predicted by PPI analysis. (D–E) Enrichment of signaling pathways based on the differentially expressed genes predicted by GSEA. (F) Concentration of 22 types of immune cells in each sample determined using an R/Cibersort Package. (G–H) Predicted binding sites between MEF2C with CXCR4 and PECAM1.