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. 2020 Dec 23;8:593653. doi: 10.3389/fcell.2020.593653

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Copyright © 2020 Liu, Zhang, Li and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Downregulation of PECAM1 and CXCR4 suppresses LPS-induced inflammation in HDPFs. (A,B) mRNA (A) and protein (B) expression of PECAM1 and CXCR4 in cells examined by RT-qPCR and western blot assays, respectively. (C–F) Levels of PGE2, TNF-α, IL-6, and IL-8 detected by ELISA kits. (G) Apoptosis of HDPFs determined by the TUNEL assay. Data were collected from three individual experiments and expressed as mean ± SD. Data were analyzed by one-way (C–G) or two-way ANOVA (A,B) followed by Tukey’s multiple comparison test. **p < 0.01 vs LPS + sh-NC; ##p < 0.01 vs. LPS + oe-NC.