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. 2020 Dec 23;8:593653. doi: 10.3389/fcell.2020.593653

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Copyright © 2020 Liu, Zhang, Li and Tian.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PEACM1 binds to CXCR4 to activate the NF-κB signaling pathway. (A,B) Co-localization of PECAM1 and CXCR4 in rat dental pulp tissues (A) and in HDPFs (B) determined by double immunofluorescence labeling. (C–D) Binding relationship between PECAM1 and CXCR4 determined by IP assays. (E–F) Phosphorylation of NF-κB p65 in rat dental pulp tissues determined by western blot analysis (E) and IHC staining, respectively. (G) Phosphorylation of NF-κB p65 in HDPFs measured by western blot analysis. (H) Sub-cellular localization of phosphorylated p65 in cells determined by immunofluorescence staining. Data were collected from three individual experiments and expressed as mean ± SD. Data were analyzed by one-way (F,H) or two-way ANOVA (E,G) followed by Tukey’s multiple comparison test. **p < 0.01.