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. 2020 Dec 23;8:615856. doi: 10.3389/fcell.2020.615856

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Copyright © 2020 Xu and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lipid synthesis and breakdown at MCSs in yeast. (A) Schematic illustration of yeast MCSs. The contact sites discussed in the text are boxed. (B) The mitochondrial and ER fractions of the PS decarboxylase Psd1, PI synthesis from CDP-DAG at MAMs, and PS transporter:ERMES complex. (C) The assembly of ER-Golgi contacts composed of the PS decarboxylase Psd2, Sfh4, the PI4P kinase Stt4, the tether Scs2 that binds Stt4, and Pbi1. (D) PI4P turnover at the ER-PM contact, and PC biosynthesis from PE. (E) LD-associated Pah1 at the nuclear vacuole junction. (F) Local phospholipid synthesis supports phagophore membrane expansion from the ER. (G) Concentration of the positive regulator of Torc1 (Ego complex) into sterol-enriched domains at ER-vacuole contacts. PME, phosphatidylmonomethylethanolamine; PDE, phosphatidyldimethylethanolamine.