TABLE 1.

Proteins involved in lipid metabolism at MCSs.

Protein	Related membrane contacts	System	References
Acyl-CoA synthetase long chain family member 1 (ACSL1)	MAM	mammalian cells	Hung et al., 2017
Carnitine palmitoyltransferase la (CPTla)	MAM	mammalian cells	Hung et al., 2017
Glycerol kinase (GK)	MAM	mammalian cells	Hung et al., 2017
IP3R-GRP75-VDAC1 complex	MAM	mammalian cells	Poston et al., 2011
Sigma-1 receptor (Sigma 1R)	MAM	mammalian cells	Hayashi and Fujimoto, 2010
Sac1 PI phosphatase	ER-PM	mammalian cells	Dickson et al., 2016
Transmembrane protein 24 (TMEM24)	ER-PM	mammalian cells	Lees et al., 2017
Sorting nexin 14 (Snx14)	ER-LD	mammalian cells	Datta et al., 2019
Oxysterol binding protein (OSBP)	ER-lysosome	mammalian cells	Lim et al., 2019
Mitoguardin 2 (MIGA2)	mitochondrion-LD	mammalian cells	Freyre et al., 2019
Adipose triglyceride lipase (ATGL)	peroxisome-LD	mammalian cells	Kong et al., 2020
ACBD2/ECI2 isoform A	peroxisome-mitochondrion	mammalian cells	Fan et al., 2016
Cholinephosphotransferase (CPT)	MAM	rat liver	Vance, 1990
Ethanolaminephosphotransferase (EPT)	MAM	rat liver	Vance, 1990
Glycerophosphate acyltransferase 1 (GPAT1)	MAV	rat liver	Pellon-Malson et al., 2007
Mitofusion2 (MFN2)	MAM	mouse liver	Sebastian et al., 2012; Hernandez-Alvarez et al., 2019
PE methyltransferase (PEMT)	MAM	rat liver	Cui et al., 1993
PS synthases PSS1/2	MAM	rat liver	Vance, 1990
PS decarboxylase1 (Psd1)	MAM	yeast	Wang et al., 2020
PI synthase (Pis)	MAM, PAM	yeast	Gaigg et al., 1995; Pichler et al., 2001
Oxysterol-binding homology 3 (Osh3)	ER-PM	yeast	Stefan et al., 2011
Opi3	ER-PM	yeast	Tavassoli et al., 2013
Ltcl	ER-Vacuole	yeast	Murley et al., 2017
Faal	ER-autophagosome	yeast	Schutter et al., 2020
PS decarboxylase2 (Psd2)	ER-Golgi	yeast	Friedman et al., 2018
Pahl	NVJ associated LD	yeast	Karanasios et al., 2013
Mdml	NVJ associated LD	yeast	Hariri et al., 2018