TABLE 1.
Respiratory parameters monitored over time. Static lung‐thorax compliance (CSTAT, ml/cmH2O), dynamic lung‐thorax compliance (CDYN, ml/cmH2O), mean airway pressure (Paw, kPa), partial pressure of oxygen (PaO2, kPa), carbon dioxide (PaCO2, kPa), oxygen saturation (SaO2, %), and arterial pH before (basal value, BV) and after induced ARDS and during 4 hrs after administration of therapy of untreated group (Control), and groups treated with poractant alfa or CHF5633 surfactant. Data are presented as means ±SD
| BV | ARDS | 30′ | 60′ | 90′ | 120′ | 150′ | 180′ | 210′ | 240′ | |
|---|---|---|---|---|---|---|---|---|---|---|
| CSTAT | ||||||||||
| Control | 2.8 ± 0.2 | 2.5 ± 0.1 | 1.9 ± 0.3 | 1.7 ± 0.1 | 1.7 ± 0.2 | 1.6 ± 0.1 | 1.5 ± 0.1 | 1.4 ± 0.1 | 1.4 ± 0.1 | 1.3 ± 0.1 |
| Poractant alfa | 2.7 ± 0.3 | 2.4 ± 0.1 | 2.0 ± 0.3 | 1.9 ± 0.3 | 1.9 ± 0.1* | 1.7 ± 0.3 | 1.6 ± 0.3 | 1.5 ± 0.2 | 1.5 ± 0.2 | 1.4 ± 0.2 |
| CHF5633 | 2.7 ± 0.2 | 2.4 ± 0.3 | 1.9 ± 0.2 | 1.8 ± 0.3 | 1.8 ± 0.2 | 1.7 ± 0.2 | 1.6 ± 0.2 | 1.5 ± 0.2 | 1.4 ± 0.2 | 1.4 ± 0.2 |
| CDYN | ||||||||||
| Control | 2.8 ± 0.5 | 1.9 ± 0.2 | 1.5 ± 0.1 | 1.4 ± 0.1 | 1.4 ± 0.1 | 1.3 ± 0.1 | 1.3 ± 0.1 | 1.2 ± 0.2 | 1.2 ± 0.1 | 1.1 ± 0.1 |
| Poractant alfa | 2.6 ± 0.5 | 1.8 ± 0.1 | 1.7 ± 0.3 | 1.7 ± 0.3 | 1.7 ± 0.2 | 1.6 ± 0.3 | 1.5 ± 0.3 | 1.4 ± 0.2 | 1.4 ± 0.3 | 1.3 ± 0.3 |
| CHF5633 | 2.9 ± 0.4 | 1.8 ± 0.2 | 1.8 ± 0.2 | 1.7 ± 0.3 | 1.6 ± 0.3 | 1.7 ± 0.3* | 1.5 ± 0.3 | 1.5 ± 0.3 | 1.4 ± 0.3 | 1.3 ± 0.2 |
| Paw | ||||||||||
| Control | 0.9 ± 0.0 | 1.2 ± 0.1 | 1.2 ± 0.1 | 1.3 ± 0.1 | 1.2 ± 0.1 | 1.3 ± 0.2 | 1.3 ± 0.2 | 1.3 ± 0.2 | 1.3 ± 0.2 | 1.3 ± 0.2 |
| Poractant alfa | 0.9 ± 0.1 | 1.2 ± 0.1 | 0.9 ± 0.1*** | 0.9 ± 0.1*** | 1.0 ± 0.1*** | 1.0 ± 0.1*** | 1.0 ± 0.1** | 1.0 ± 0.1** | 1.1 ± 0.1** | 1.1 ± 0.1** |
| CHF5633 | 0.9 ± 0.0 | 1.2 ± 0.1 | 0.9 ± 0.1*** | 0.9 ± 0.1*** | 1.0 ± 0.1*** | 1.0 ± 0.1*** | 1.0 ± 0.1** | 1.0 ± 0.1** | 1.1 ± 0.1** | 1.1 ± 0.1** |
| PaO2 | ||||||||||
| Control | 41.9 ± 5.1 | 6.0 ± 1.9 | 6.8 ± 1.2 | 8.2 ± 1.4 | 8.2 ± 1.8 | 8.7 ± 1.9 | 8.7 ± 2.6 | 9.5 ± 3.8 | 10.3 ± 7.3 | 11.5 ± 9.8 |
| Poractant alfa | 46.4 ± 4.4 | 7.2 ± 3.3 | 43.0 ± 20.2*** | 45.1 ± 16.0*** | 45.6 ± 16.8*** | 45.8 ± 17.9*** | 43.7 ± 13.5*** | 45.4 ± 16.7*** | 40.3 ± 17.2*** | 42.1 ± 19.1*** |
| CHF5633 | 45.2 ± 3.5 | 6.6 ± 3.2 | 34.1 ± 15.1** | 41.4 ± 16.4*** | 36.8 ± 13.1*** | 37.5 ± 12.4*** | 37.8 ± 11.5*** | 38.7 ± 10.7*** | 42.7 ± 11.1*** | 41.7 ± 13.2*** |
| PaCO2 | ||||||||||
| Control | 5.8 ± 1.6 | 4.0 ± 0.9 | 6.1 ± 1.2 | 6.3 ± 0.9 | 6.6 ± 1.0 | 6.7 ± 1.1 | 6.7 ± 0.8 | 6.8 ± 0.9 | 7.0 ± 0.9 | 7.1 ± 0.7 |
| Poractant alfa | 6.0 ± 1.2 | 4.4 ± 1.4 | 6.7 ± 1.6 | 6.7 ± 1.7 | 6.9 ± 1.5 | 6.9 ± 1.2 | 6.8 ± 1.0 | 7.0 ± 1.2 | 7.1 ± 1.1 | 7.3 ± 1.3 |
| CHF5633 | 6.4 ± 1.6 | 4.5 ± 1.0 | 6.3 ± 0.7 | 6.3 ± 0.7 | 6.5 ± 0.8 | 6.5 ± 0.6 | 6.6 ± 0.6 | 7.1 ± 0.7 | 6.9 ± 0.8 | 7.2 ± 1.2 |
| SaO2 | ||||||||||
| Control | 97.2 ± 1.5 | 75.6 ± 13.4 | 77.8 ± 6.7 | 84.9 ± 4.1 | 83.0 ± 6.4 | 85.3 ± 4.6 | 84.1 ± 5.1 | 84.9 ± 5.6 | 83.0 ± 5.9 | 84.1 ± 5.8 |
| Poractant alfa | 96.9 ± 1.6 | 80.3 ± 9.5 | 96.1 ± 1.7*** | 96.2 ± 2.2*** | 96.1 ± 2.1*** | 96.0 ± 2.4*** | 96.4 ± 1.6*** | 96.2 ± 2.3*** | 96.0 ± 2.1*** | 95.7 ± 2.0*** |
| CHF5633 | 96.1 ± 1.4 | 78.2 ± 7.1 | 95.3 ± 2.0*** | 95.8 ± 1.5*** | 95.7 ± 1.5*** | 95.7 ± 1.5*** | 95.8 ± 1.5*** | 95.7 ± 1.5*** | 95.8 ± 1.5*** | 95.6 ± 1.6*** |
| pH | ||||||||||
| Control | 7.5 ± 0.1 | 7.6 ± 0.1 | 7.4 ± 0.1 | 7.4 ± 0.1 | 7.4 ± 0.1 | 7.4 ± 0.1 | 7.3 ± 0.1 | 7.3 ± 0.1 | 7.3 ± 0.1 | 7.3 ± 0.1 |
| Poractant alfa | 7.5 ± 0.1 | 7.6 ± 0.1 | 7.4 ± 0.1 | 7.4 ± 0.1 | 7.4 ± 0.1 | 7.4 ± 0.0 | 7.4 ± 0.0 | 7.3 ± 0.0 | 7.3 ± 0.1 | 7.3 ± 0.1 |
| CHF5633 | 7.5 ± 0.1 | 7.6 ± 0.1 | 7.4 ± 0.1 | 7.4 ± 0.1 | 7.4 ± 0.1 | 7.4 ± 0.1 | 7.4 ± 0.1 | 7.4 ± 0.1 | 7.4 ± 0.1 | 7.4 ± 0.1 |
Statistical comparisons: for Poractant alfa and CHF5633 vs. control.
*
p < 0.05,
**
p < 0.01,
***
p < 0.001.