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. 2021 Jan 5;325(1):59–68. doi: 10.1001/jama.2020.23567

Table 2. Causes of Acutely Worsening Respiratory Symptoms at Hospital Admission in Patients With Chronic Obstructive Pulmonary Disease After Pulmonary Embolism Assessment.

Inclusion delay, h No. of patients Anticoagulation, No.a Hospitalization length, median (IQR), d At 3 mo, No.
Preventive Curative Pulmonary embolism follow-up All-cause death
Pulmonary embolismb
Total No. 44 9.0 (7.0-14.0)
≤24 43 0 0 0 12
>24-≤48 1 0 1 0 0
Deep vein thrombosisc
Total No. 10 10.0 (7.0-38.0)
≤24 10 0 10 0 2
>24-≤48 0
Bacterial bronchial infectiond
Total No. 462 7.0 (4.0-10.0)
≤24 452 108 6 3 19
>24-≤48 10 4 0 0 0
Pneumoniae
Total No. 69 8.0 (5.0-10.5)
≤24 66 26 0 0 6
>24-≤48 3 3 0 0 0
Undetermined respiratory failure
Total No. 69 6.0 (3.0-10.0)
≤24 67 24 1 10 3
>24-≤48 2 22 0 0 0
Pneumothoraxf
Total No. 2 8.5 (3.0-14.0)
≤24 2 1 0 0 0
>24-≤48 0
Atrial fibrillation
Total No. 4 9.0 (4.5-14.0)
≤24 4 0 4 0 0
>24-≤48 0
Left cardiac failure
Total No. 42 8.0 (5.0-11.0)
≤24 42 6 2 0 4
>24-≤48 0
New cancer or worsening of previous cancer
Total No. 10 10.5 (6.0-20.0)
≤24 10 2 1 0 3
>24-≤48 0
Iatrogenic
Total No. 2 12.5 (9.0-16.0)
≤24 2 0 0 0 0
>24-≤48 0
Otherg
Total No. 26 5.5 (3.0-15.0)
≤24 26 6 5 1 1
>24-≤48 0

Abbreviation: IQR, interquartile range.

a

Anticoagulation administered before inclusion.

b

One patient was classified as having adjudicated pulmonary embolism with bacterial infection.

c

Nine patients were classified as having adjudicated deep vein thrombosis: 2 patients also had pneumonia; 4, bacterial infection; and 3 worsening respiratory symptoms without evidence for bacterial infection and not requiring antibiotics.

d

Bacterial infection was based on respiratory failure requiring antibiotics without evidence for pneumonia.

e

Worsening respiratory symptoms without evidence for bacterial infection and not requiring antibiotics.

f

Two incomplete pneumothorax, not detected on chest x-ray at hospital admission, were diagnosed on spiral computed tomographic pulmonary angiography performed at inclusion.

g

No detail was collected for patients classified as “other.”