Table 8.
Interaction between FcgRIIA/RIIIA/RIIIB combined genotypes—environmental exposure and malaria infections.
| FcgR genotypes combinations*exposure to malaria | n | IRR | 95% CI | P value |
|---|---|---|---|---|
| 131RR/176FF/NA2NA2*low exposure (reference) | 9 | |||
| 131RR/176FF/NA2NA2*high exposure | 12 | 0.737 | 0.356; 1.524 | 0.411 |
| 131RR/176FF/NA1NA2*low exposure | 10 | 0.947 | 0.498; 1.801 | 0.869 |
| 131RR/176FF/NA1NA2*high exposure | 16 | 0.729 | 0.354; 1.503 | 0.393 |
| 131RR/176FF/NA1NA1*low exposure | 5 | 1.078 | 0.508; 2.284 | 0.844 |
| 131RR/176FF/NA1NA1*high exposure | 4 | 1.293 | 0.573; 2.917 | 0.535 |
| 131RR/176FV/NA2NA2*low exposure | 7 | 1.052 | 0.513; 2.158 | 0.889 |
| 131RR/176FV/NA2NA2*high exposure | 5 | 1.230 | 0.486; 3.113 | 0.662 |
| 131RR/176FV/NA1NA2*low exposure | 3 | 0.219 | 0.028; 1.692 | 0.146 |
| 131RR/176FV/NA1NA2*high exposure | 7 | 0.488 | 0.185; 1.286 | 0.147 |
| 131RR/176FV/NA1NA1*low exposure | 3 | 0.880 | 0.284; 2.726 | 0.825 |
| 131RR/176FV/NA1NA1*high exposure | 1 | 0.621 | 0.138; 2.793 | 0.535 |
| 131RR/176VV/NA1NA2*low exposure | 1 | 0.796 | 0.224; 2.821 | 0.724 |
| 131RH/176FF/NA2NA2*low exposure | 14 | 1.018 | 0.536; 1.933 | 0.955 |
| 131RH/176FF/NA2NA2*high exposure | 8 | 1.385 | 0.728; 2.634 | 0.320 |
| 131RH/176FF/NA1NA2*low exposure | 11 | 0.801 | 0.403; 1.595 | 0.529 |
| 131RH/176FF/NA1NA2*high exposure | 15 | 0.883 | 0.464; 1.680 | 0.706 |
| 131RH/176FF/NA1NA1*low exposure | 10 | 0.998 | 0.478; 2.084 | 0.997 |
| 131RH/176FF/NA1NA1*high exposure | 21 | 1.176 | 0.638; 2.169 | 0.602 |
| 131RH/176FV/NA2NA2*low exposure | 23 | 0.952 | 0.504; 1.799 | 0.881 |
| 131RH/176FV/NA2NA2*high exposure | 14 | 1.287 | 0.685; 2.418 | 0.431 |
| 131RH/176FV/NA1NA2*low exposure | 13 | 0.445 | 0.194; 1.017 | 0.055 |
| 131RH/176FV/NA1NA2*high exposure | 10 | 1.147 | 0.598; 2.201 | 0.679 |
| 131RH/176FV/NA1NA1*low exposure | 17 | 0.752 | 0.381; 1.484 | 0.412 |
| 131RH/176FV/NA1NA1*high exposure | 15 | 1.207 | 0.629; 2.318 | 0.571 |
| 131RH/176VV/NA2NA2*low exposure | 5 | 0.642 | 0.206; 2.001 | 0.445 |
| 131RH/176VV/NA1NA2*low exposure | 3 | 1.778 | 0.720; 4.386 | 0.211 |
| 131RH/176VV/NA1NA2*high exposure | 3 | 1.675 | 0.761; 3.688 | 0.200 |
| 131RH/176VV/NA1NA1*low exposure | 2 | 0.381 | 0.049; 2.933 | 0.355 |
| 131RH/176VV/NA1NA1*high exposure | 3 | 0.733 | 0.164; 3.280 | 0.685 |
| 131HH/176FF/NA2NA2*low exposure | 2 | 1.013 | 0.286; 3.591 | 0.983 |
| 131HH/176FF/NA2NA2*high exposure | 3 | 1.855 | 0.746; 4.609 | 0.183 |
| 131HH/176FF/NA1NA2*low exposure | 3 | 0.481 | 0.134; 1.719 | 0.260 |
| 131HH/176FF/NA1NA2*high exposure | 3 | 0.454 | 0.058; 3.496 | 0.449 |
| 131HH/176FF/NA1NA1*low exposure | 2 | 2.622 | 0.978; 7.029 | 0.055 |
| 131HH/176FF/NA1NA1*high exposure | 5 | 1.332 | 0.498; 3.559 | 0.567 |
| 131HH/176FV/NA2NA2*high exposure | 7 | 0.943 | 0.375; 2.371 | 0.901 |
| 131HH/176FV/NA1NA2*low exposure | 10 | 1.033 | 0.504; 2.118 | 0.927 |
| 131HH/176FV/NA1NA2*high exposure | 10 | 0.955 | 0.486; 1.876 | 0.895 |
| 131HH/176FV/NA1NA1*low exposure | 6 | 0.362 | 0.103; 1.275 | 0.114 |
| 131HH/176FV/NA1NA1*high exposure | 8 | 0.791 | 0.381; 1.641 | 0.530 |
| 131HH/176VV/NA2NA2*low exposure | 2 | 1.520 | 0.535; 4.319 | 0.431 |
| 131HH/176VV/NA2NA2*high exposure | 3 | 1.724 | 0.835; 3.559 | 0.140 |
| 131HH/176VV/NA1NA2*low exposure | 4 | 0.366 | 0.047; 2.828 | 0.336 |
| 131HH/176VV/NA1NA2*high exposure | 5 | 1.888 | 0.922; 3.867 | 0.082 |
| 131HH/176VV/NA1NA1*low exposure | 2 | 1.328 | 0.430; 4.099 | 0.622 |
| 131HH/176VV/NA1NA1*high exposure | 2 | 1.752 | 0.673; 4.562 | 0.251 |
This table presents the zero inflated negative binomial model, with the interaction between FcgR and environmental exposure obtained through the control variables mother age (in years), child age (in months), number of antenatal visits, and use of bednet.
Underlined: trend of significance at the P value threshold of 0.05.