Table 2.

Significant changes in phenotype and function of immune cells induced by HLA-G.

	Changes in phenotype		Changes in function
	Up-regulated expression	Down-regulated expression
NK cell	ILT2, ILT3, ILT4, KIR2DL4, TNF-α, IFN-γ, MIP-1, MIP-3, IL-1β, IL-6, IL-8, IL-23	CXCR3, CX3CR1, CCR2	Inhibition of cytotoxic function, proliferation, and chemotaxis Induction of apoptosis Increased secretion of pro-angiogenic factors
CD4+ T cell	ILT2, ILT3, ILT4, KIR2DL4, IL-3, IL-4, IL-10	CD4, CCR2, CXCR3, CXCR5, TNF-α, IFN-γ	Inhibition of alloreactivity, proliferation, and chemotaxis Induction of anti-inflammatory response by shifting the Th1/Th2 balance Induction of regulatory/suppressive cells
CD8+ T cell	ILT2, ILT3, ILT4, KIR2DL4	CXCR3	Inhibition of cytotoxic function, proliferation, and chemotaxis Induction of apoptosis Induction of regulatory cells
DCs	ILT2, ILT3, ILT4, KIR2DL4, IL-1β, CD83a	HLA-DR, CD80, CD86, HLA-DM, GILT, CD74, LAMP3, Dynactin 2, Dectin-1, DCSTAMP	Inhibition of maturation Induction of tolerogenic state Induction of T cell tolerance
Macrophage	CD163, IDO-1, IL-6, CXCL1, IL-12, TGF-β	CD86	Inhibition of phagocytic function Induction of differentiation toward M2-like phenotype
B cell		CXCR4, CXCR5	Inhibition of Ig secretion, proliferation, and chemotaxis
Neutrophil		Reactive oxygen species	Inhibition of phagocytic function