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Schematic representation of DEHP transgenerational effects on allergic lung inflammation. Chronic and low-dose exposure to a common plasticizer, DEHP, may enhance allergic lung inflammation in young offspring through at least four generations. Ancestral DEHP exposure leads to trans-generational hypo-methylation of the Igf2r gene locus, increased expression of Igf2r mRNA and protein, altered homeostasis of DC subsets, and enhanced allergic lung inflammation.
