Table 1.
Prefrontal–hippocampal activity patterns and coupling in CON, GHPE, and GE mice
| CON | GHPE | GE | F value | |||
|---|---|---|---|---|---|---|
| HP | Occurrence (per min) | 8.73 ± 0.31 | 9.52 ± 0.29 | 9.47 ± 0.38 | F(2,53) = 1.94 P = 0.15 | |
| Spindle bursts | Duration (s) | 4.46 ± 0.24 | 3.67 ± 0.15 *P = 0.021 | 3.38 ± 0.18 **P = 0.0005 | F(2,53) = 8.72 P = 0.0005 | |
| Power (4–50 Hz) | 30.63 ± 4.93 | 12.37 ± 1.72 *P = 0.034 | 18.23 ± 3.32 *P = 0.05 | F(2,53) = 5.87 P = 0.005 | ||
| SPWs | Occurrence (Hz) | 0.41 ± 0.02 | 0.37 ± 0.02 *P = 0.034 | 0.36 ± 0.02 *P = 0.024 | F(2,52) = 2.73 P = 0.05 | |
| SWP-Spike | 0.76 ± 0.08 | 0.40 ± 0.11 *P = 0.019 | 0.47 ± 0.09 *P = 0.05 | F(2,51) = 4.74 P = 0.013 | ||
| PL | Occurrence (per min) | 7.88 ± 0.33 | 8.87 ± 0.26 | 8.07 ± 0.39 | F(2,47) = 2.60 P = 0.09 | |
| Spindle bursts | Duration (s) | 3.05 ± 0.17 | 2.47 ± 0.13 *P = 0.030 | 2.41 ± 0.17 *P = 0.021 | F(2,47) = 5.29 P = 0.008 | |
| Power (4–50 Hz) | 10.12 ± 1.31 | 6.41 ± 0.60 *P = 0.049 | 6.33 ± 0.94 *P = 0.029 | F(2,53) = 4.49 P = 0.016 | ||
| MUA | Layer2/3 (log) | −0.71 ± 0.16 | −0.45 ± 0.21 | −1.96 ± 0.24 *P = 0.030 | F(2,39) = 3.55 P = 0.038 | |
| Layer5/6 (log) | −3.06 ± 0.30 | −2.18 ± 0.35 | −3.36 ± 0.61 | F(2,39) = 2.35 P = 0.108 | ||
| HP-PL | PLV (4–30 Hz) | 0.19 ± 0.01 | 0.15 ± 0.02 *P = 0.037 | 0.15 ± 0.01 *P = 0.049 | F(2,51) = 4.20 P = 0.021 | |
| gPDC (4–30 Hz) | 0.068 ± 0.004 | 0.050 ± 0.004 *P = 0.014 | 0.053 ± 0.005 *P = 0.036 | F(2,53) = 5.26 P = 0.008 |
Data are shown as mean ± SEM. Significance was assessed using one-way ANOVA test followed by Bonferroni-corrected post hoc test and the listed P values correspond to comparisons between CON and GHPE mice, CON and GE mice. *P < 0.05, **P < 0.01.