Table 2.
Prefrontal–hippocampal activity patterns and coupling induced by activating CA1
| CON | GHPE | GE | F values | |||
|---|---|---|---|---|---|---|
| Activating HP by pulses stimulation | ||||||
| 4–12 Hz | 0.234 ± 0.049 | 0.059 ± 0.042 *P = 0.016 | 0.023 ± 0.047 **P = 0.005 | F(2,45) = 6.47 P = 0.0034 | ||
| PFC | Power (During-pre)/pre | 12–30 Hz | 0.210 ± 0.049 | 0.045 ± 0.032 **P = 0.0096 | −0.007 ± 0.039 **P = 0.0011 | F(2,45) = 8.21 P = 0.0009 |
| 30–45 Hz | 0.184 ± 0.035 | 0.051 ± 0.027 **P = 0.007 | 0.004 ± 0.030 ***P = 0.0004 | F(2,45) = 9.38 P = 0.0004 | ||
| Activating HP by ramp stimulation | ||||||
| 4–12 Hz | 0.186 ± 0.045 | 0.070 ± 0.031 *P = 0.011 | 0.026 ± 0.050 *P = 0.024 | F(2,45) = 3.98 P = 0.026 | ||
| HP | Power (During-pre)/pre | 12–30 Hz | 0.267 ± 0.051 | 0.091 ± 0.043 *P = 0.018 | 0.046 ± 0.043 **P = 0.004 | F(2,45) = 6.62 P = 0.003 |
| 30–45 Hz | 0.224 ± 0.054 | 0.102 ± 0.046 | 0.089 ± 0.049 | F(2,45) = 2.34 P = 0.108 | ||
| Spike-triggered LFP | 15–40 Hz | 3.08 ± 0.59 | 1.43 ± 0.27 *P = 0.018 | 1.42 ± 0.40 *P = 0.021 | F(2,43) = 5.26 P = 0.009 | |
| PFC2/3 | Firing interval | 0.020 ± 0.001 | 0.015 ± 0.002 *P = 0.04 | 0.014 ± 0.002 **P = 0.005 | F(2,39) = 6.37 P = 0.004 | |
| HP spike-triggered LFP | 15–40 Hz | 7.06 ± 2.19 | 3.03 ± 0.72 *P = 0.044 | 2.90 ± 0.88 *P = 0.042 | F(2,45) = 3.22 P = 0.049 | |
| PFC-HP | Coherence | 12–18 Hz | 0.220 ± 0.044 | 0.041 ± 0.023 ***P = 0.0003 | −0.004 ± 0.024 ***P = 0.00001 | F(2,41) = 15.33 P = 0.000001 |
Data are shown as mean ± SEM. Significance was assessed using one-way ANOVA test followed by Bonferroni-corrected post hoc test and the listed P values correspond to comparisons between CON and GHPE mice, CON and GE mice. *P < 0.05, **P < 0.01, ***P < 0.001.