Figure 2.

Visual illustration of the ssPCC estimation of single sample network. (A) For a group of n reference samples, a reference network PCC_n can be constructed using Pearson’s correlations. (B) A new sample q is added and the perturbed network PCC_n+1 with this additional sample is calculated. The difference between PCC_n and PCC_n+1 is due to sample q. (C) Differential network ΔPCC_n is constructed taking the difference between perturbed and the reference network PCC_nn + 1 – PCC_n. Figure reproduced and adapted from the original publication,¹³ published under Creative Commons license CC BY-NC-ND.