Table 1.

Representative bioactive neural lipids, their cellular receptors, and their cellular effects on dopamine cells.

	Cellular receptors	Effects on dopamine cells
Endocannabinoids
2-arachidonoylglycerol (2-AG)	CB1 (Sugiura et al., 1995), CB2 (Mechoulam et al., 1995)	Short-term synaptic depression of glutamate and GABA inputs (Melis et al., 2004a)
Arachidonoylethanolamide (Anandamide) (a cannabinoid N-acylethanolamine)	CB1 (Devane et al., 1992), CB2 (Mechoulam et al., 1995), TRPV1 (Zygmunt et al., 1999)	Facilitation of glutamate release and excitation (via TRPV1; Marinelli et al., 2003; Melis et al., 2008)
Non-cannabinoid N-acylethanolamines
Oleoylethanolamide	PPARα (Fu et al., 2003)	Phosphorylation and negative modulation of β*-nAChRs (Melis et al., 2008)
Palmitoylethanolamide	PPARα (Lo Verme et al., 2005)	Phosphorylation and negative modulation of β*-nAChRs (Melis et al., 2008)
N-acyl amino acids
Oleoylglycine	PPARα (Takao et al., 2015; Donvito et al., 2019)	Unknown

See text for abbreviations.