Table 1.

Concentration and duration of exposure to cisplatin (CIS) based on the extracted data.

Article	Cisplatin concentration	Duration of exposure to cisplatin	Experimental flow
Vlasits et al. 12	0–100 µM	24 h	Pre-treatment for 1 h, then co-exposure for 24 h
Todd et al. 5	0–1000 µM	4 h	CIS exposure for 4 h
Monroe et al. 35	100 µM	45 min	Co-exposure for 45 min
Hong et al. 24	1000 µM	4 h	Co-exposure for 4 h
Lee et al. 23	1000 µM	4 h	Co-exposure for 4 h
Choi et al.42	1000 µM	6 h	Co-exposure for 6 h
Min et al. 26	1000 µM	6 h	Pre-treatment for 150 min, then CIS exposure for 6 h
Niihori et al. 6	1000 μM	4 h	Pre-treatment for 12 h, then co-exposure for 4 h
Monroe et al. 33	100–500 µM	45 min	CIS exposure for 45 min,regeneration for 3 h, then co-exposure for 15 h (cell culture)
Coffin et al. 31	250–1000 µM	6 h	Pre-treatment for 1 h, then co-exposure for 6 h
Uribe et al. 18	250–1500 μM	4 h	Co-exposure for 4  h
Kitcher et al. 30	25–200 µM	24 h	Co-exposure for 24 h
Monroe et al.36	25 mg/kg	Single microinjection	CIS microinjection, 24 after drug microinjection
Mackenzie and Raible 29	50 µM	24 h	Co-exposure for 24 h
Shin et al. 37	50 µM	24 h	Pre-treatment for 1 h, then CIS exposure for 24 h
Thomas et al. 27	50 µM	24 h	Pre-treatment for 1 h, then CIS exposure for 24 h
Zheng et al. 38	50 µM	24 h	Pre-treatment for 2 h, then co-exposure for 24 h
Hirose et al. 22	50 µM	6 h	Co-exposure for 6 h
Kruger et al. 25	500 µM	6 h	Co-exposure for 6 h
Vargo et al. 21	50–200 µM	16 h	Co-exposure for 16 h
Thomas et al. 19	50–500 µM	6 and 24 h	Pre-treatment for 1 h, then co-exposure for 6 h and 24 h
Rocha-Sanchez et al. 34	50–800 µM	6 h	Pre-treatment for 2 h, then co-exposure for 6 h
Gu et al. 39	60 µM	24 h	Pre-treatment for 4 h, then CIS exposure for 24 h
Pang et al. 28	600 µM	12 and 24 h	Pre-treatment for 1 h, then co-exposure for 12 h and 24 h
Wang et al. 40	Data not available	24 h	Co-exposure for 24 h