Table 2.
The experimental conditions of otoprotective experiments.
| Article | Name of substance | Functional target | The optimal concentration of otoptotective substance | Cisplatin concentration | Experimental flow |
|---|---|---|---|---|---|
| Monroe et al. 36 | CLEFMA and EF24 | Oxidative stress | 5 mg/kg | 25 mg/kg | CIS microinjection, 24 h after the compound microinjection |
| Monroe et al. 35 | L-Serine | Oxidative stress | 100 µM | 100 µM | Co-exposure for 45 min |
| Hong et al. 24 | Edaravone | Oxidative stress | 750 µM | 1000 µM | Co-exposure for 4 h |
| Lee et al. 23 | Quercetin | Oxidative stress | 100 µM | 1000 µM | Co-exposure for 4 h |
| Choi et al. 42 | Apocynin | Oxidative stress | 125–250 µM | 1000 µM | Co-exposure for 6 h |
| Kruger et al.25 | Berbamine | MET-channel | 1 and 10 µM | 500 µM | Co-exposure for 6 h |
| Vargo et al. 21 | Mdivi-1 | MET-channel | 3–7 µM | 50-100 µM | Co-exposure for 16 h |
| Kitcher et al. 30 | ORC-13661 | MET-channel | 2.2 µM | 200 µM | Co-exposure for 24 h |
| Wang et al. 39 | NAC | Oxidative stress | Data not available | 1000 µM | Co-exposure for 24 h |
| Wang et al. 39 | CYM-5478 | Oxidative stress | Data not available | 20 µM | Co-exposure for 24 h |
| Shin et al. 37 | KR-22335 | Oxidative stress | 1, 10, 100 µg/mL | 50 µM | Pre-treatment for 60 min, then CIS exposure for 24 h |
| Thomas et al. 27 | CHCP2 | Oxidative stress | 100 µM | 50 µM | Pre-treatment for 60 min, then CIS exposure for 24 h |
| Pang et al. 28 | Rapamycin | Autophagy | 10 µM | 600 µM | Pre-treatment for 60 min, then co-exposure for 12 h |
| Pang et al. 28 | SRT1720 | Autophagy | 5 µM | 600 µM | Pre-treatment for 60 min, then co-exposure for 12 h |
| Vlasits etal. 12 | Benzamil | MET-channel | 50 µM | 0–100 µM | Pre-treatment for 60 min, then co-exposure for 24 h |
| Coffin et al. 31 | Leupeptin | Calpains | 500 µM | 250 µM | Pre-treatment for 60 min, then co-exposure for 6 h |
| Coffin et al. 31 | Z-LLF-CHO | Protease | 25 µM | 750 µM | Pre-treatment for 60 min, then co-exposure for 6 h |
| Coffin et al. 31 | FUT-175 | Proteasome | 10 µM | 500–1000 µM | Pre-treatment for 60 min, then co-exposure for 6 h |
| Coffin et al. 31 | D-methionine | Oxidative stress | 5 mM | 250–1000 µM | Pre-treatment for 60 min, then co-exposure for 6 h |
| Coffin et al. 31 | 3-MA | Autophagy | 5 mM | 250, 750 µM | Pre-treatment for 60 min, then co-exposure for 6 h |
| Thomas et al. 19 | Quinine | MET-channel | 100 µM | 250–500 µM | Pre-treatment for 60 min, then co-exposure for 6 h |
| Zheng et al. 38 | Sal B | Oxidative stress | 40 µM | 0–50 µM | Pre-treatment for 120 min, then co-exposure for 24 h |
| Rocha-Sanchez et al. 34 | Quinoxaline | Oxidative stress | 300 µM | 50–400 µM | Pre-treatment for 120 min, then co-exposure for 6 h |
| Min et al. 26 | Dexmedetomidine | Oxidative stress | 0.1, 1, 10 µM | 1000 µM | Pre-treatment for 150 min, then CIS exposure for 6 h |
| Gu et al. 40 | ATX-LPN | Oxidative stress | 50 μg/mL | 60 µM | Pre-treatment for 240 min, then CIS exposure for 24 h |