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. 2020 Dec 22;8:611796. doi: 10.3389/fbioe.2020.611796

Figure 4.

Figure 4

Quantitative analysis of tumor spheroid behavior in composite hydrogel. (A,B) The spheroid roughness and size comparison of four kinds of tumor microspheres in Matrigel and composite hydrogel. Inserted image shows the invadopodia-like protrusions inside of the both Matrigel and L-G-C composite hydrogel. (C) The drug efficacy to cancer cells tested in Matrigel and L-G-C composite hydrogel. N = 3 for each experiment. Error bars indicate the S.E.M of the data variation. Significance were indicated with *P < 0.05, **P < 0.01 (one way ANNOVA with Tukey back test). Scale bar: 50 μm.