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. 2020 Nov 15;202(10):1445–1457. doi: 10.1164/rccm.201910-2041OC

Figure 2.

Figure 2.

TYKRIL (tyrosine kinase receptor–inducing long noncoding RNA) induced the proproliferative and antiapoptotic phenotype in lung pericytes and human pulmonary arterial smooth muscle cells (hPASMCs) under idiopathic pulmonary arterial hypertension (IPAH) and hypoxic conditions. (A–D) Knockdown of TYKRIL using GapmeRs in both lung pericytes and hPASMCs. (E–H) The proproliferative phenotype induced under these conditions was reversed with TYKRIL knockdown in lung pericytes and hPASMCs (n = 3). (I–L) Increased apoptosis was observed with TYKRIL knockdown in lung pericytes and hPASMCs exposed to hypoxia and isolated from patients with IPAH (n = 3). One-way ANOVA followed by Dunnett’s multiple comparison test, $P = 0.08, *P < 0.05, **P < 0.01, and ***P < 0.001 compared with control. Ctrl = control; LNA = locked nucleic acid.