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. 2020 Dec 1;146(6):e2020002725. doi: 10.1542/peds.2020-002725

TABLE 2.

Treatment Effect on Bayley-III Composite Score and the Strengths and Difficulties Questionnaire

Point Estimate CI: Lower Bound CI: Upper Bound P (Unadjusted) P (Adjusted) n
Panel 1: Bayley-III composite scores baseline to midline
 Nutritional education
  Cognitive −0.144 −0.320 0.033 .082 .359 1270
  Language 0.037 −0.144 0.217 .613 .956 1273
  Motor −0.036 −0.223 0.150 .683 .956 1269
 Group sessions and nutritional education
  Cognitive 0.298 0.104 0.493 .004 .018 1270
  Language 0.313 0.115 0.510 .004 .006 1273
  Motor 0.011 −0.210 0.232 .900 .956 1269
 Home visiting and nutritional education
  Cognitive 0.313 0.132 0.494 .002 .006 1270
  Language 0.156 −0.053 0.365 .090 .359 1273
  Motor −0.058 −0.262 0.146 .611 .956 1269
Panel 2: Bayley-III composite scores baseline to endline
 Nutritional education
  Cognitive 0.037 −0.145 0.220 .673 .709 1298
  Language 0.127 −0.038 0.292 .103 .342 1298
  Motor 0.075 −0.087 0.238 .354 .657 1298
 Group sessions and nutritional education
  Cognitive 0.281 0.100 0.463 .002 .007 1298
  Language 0.302 0.136 0.468 <.001 .001 1298
  Motor 0.144 −0.036 0.324 .110 .342 1298
 Home visiting and nutritional education
  Cognitive 0.324 0.152 0.496 <.001 .001 1298
  Language 0.239 0.072 0.407 .001 .009 1298
  Motor 0.055 −0.108 0.218 .475 .709 1298
Panel 3: Strengths and Difficulties Questionnaire
 Nutritional education
  Externalizing 0.010 −0.157 0.177 .900 .991 1297
  Internalizing −0.058 −0.209 0.094 .438 .949 1297
  Prosocial 0.073 −0.082 0.229 .328 .903 1297
 Group sessions and nutritional education
  Externalizing −0.039 −0.211 0.134 .651 .981 1297
  Internalizing −0.008 −0.151 0.134 .908 .991 1297
  Prosocial 0.179 0.021 0.336 .018 .126 1297
 Home visiting and nutritional education
  Externalizing 0.043 −0.117 0.204 .583 .981 1297
  Internalizing −0.025 −0.172 0.122 .750 .981 1297
  Prosocial 0.215 0.057 0.373 .008 .054 1297

Estimated coefficients are expressed in SDs of the control group. Sample size includes all target children who completed the relevant subscales of the Bayley-III at endline and midline for panel 1, and at endline for panel 2, and all mothers who completed the Strengths and Difficulties Questionnaire (at endline) in panel 3. Estimates in all panels controlled for baseline ASQ-3 problem solving, communication, fine motor, gross motor, and personal-social scales, as well as child sex, child age in days, maternal education, and parity with a dummy for first child. Estimated coefficients are expressed in SDs of the control group. The P values are two-tailed P values calculated using the T-bootstrap method (5000 replications) to account for the finite sample and for maximum comparability with the adjusted P values. Adjusted P values are two-tailed P values corrected for multiple hypotheses testing by using the Romano–Wolf stepdown procedure (5000 replications). CIs were constructed by using conventional critical values for individual hypotheses. The multiple hypotheses testing was applied within panels. All replications were done within district used in the randomization protocol and corrected for cluster effects at the village level.