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. 2021 Jan 5;13:11. doi: 10.1186/s13195-020-00742-y

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Correlation of global Aβ deposition and hippocampal SV2A in aMCI and dementia due to AD. Scatter plot with best-fit lines depicts a significant inverse association between global Aβ deposition and hippocampal SV2A in participants with aMCI (green) but not with dementia (red). Correlation coefficients were calculated from separate univariate linear regression analyses in each group with associated two-tailed P values, without correction for multiple comparisons. Global Aβ deposition was calculated by averaging values of [¹¹C] PiB DVR from the bilateral prefrontal, lateral temporal, posterior cingulate/precuneus, and lateral parietal ROIs, weighted by volume. Green circles denote DVR values for aMCI participants, while red circles denote DVR values for participants with dementia. Abbreviations: DVR, distribution volume ratio using a whole cerebellum reference region; aMCI: amnestic mild cognitive impairment; SV2A, synaptic vesicle glycoprotein 2A; PiB, Pittsburgh Compound B