Table 2.

Correlation of global Aβ deposition and regional SV2A in aMCI and dementia due to AD

	Mild cognitive impairment (n = 14)		Dementia (n = 24)		Fisher z-transform
Primary region	Pearson r	P	Pearson r	P	z	P
Hippocampus	−0.55	0.04*	0.05	0.82	−1.80	0.04
Exploratory regions	Pearson r	P	Pearson r	P	z	P
Entorhinal	−0.08	0.77	0.10	0.65	−0.49	0.31
Parahippocampal	−0.29	0.31	0.01	0.97	−0.83	0.20
Amygdala	−0.43	0.13	0.04	0.87	−1.34	0.09
Lateral temporal	−0.26	0.38	−0.10	0.65	−0.45	0.33
Prefrontal	−0.02	0.95	−0.21	0.32	0.52	0.30
PCC/precuneus	−0.12	0.69	−0.32	0.12	0.57	0.29
Anterior cingulate	0.07	0.80	−0.05	0.82	0.32	0.37
Lateral parietal	−0.18	0.53	−0.43	0.03*	0.75	0.23
Lateral occipital	−0.13	0.66	−0.32	0.13	0.54	0.30
Medial occipital	−0.10	0.73	−0.19	0.37	0.25	0.40
Pericentral	0.00	0.99	−0.17	0.44	0.46	0.32

Data are Pearson r and associated two-tailed P values obtained from separate univariate linear regression analyses in each group, uncorrected for multiple comparisons. Global Aβ deposition was calculated by averaging values of [¹¹C] PiB DVR from the bilateral prefrontal, lateral temporal, posterior cingulate/precuneus, and lateral parietal ROIs, weighted by volume. Global Aβ deposition was then correlated with [¹¹C]UCB-J DVR from the 4 medial temporal structures and 8 neocortical ROIs. To determine significant differences between group correlation coefficients, Fisher z-transformations and associated one-tailed P values were reported. * denotes significant correlation, with P < 0.05. Abbreviations: PCC posterior cingulate cortex, PiB Pittsburgh Compound B, SV2A synaptic vesicle glycoprotein 2A, DVR distribution volume ratio using a whole cerebellum reference region, ROI region of interest, aMCI amnestic mild cognitive impairment