Table 3.

Correlation of regional Aβ deposition and regional SV2A in aMCI and dementia due to AD

	Mild cognitive impairment (n = 14)		Dementia (n = 24)
Primary region	Pearson r	P	Pearson r	P
Hippocampus	0.40	0.16	0.63	0.001*
Exploratory regions	Pearson r	P	Pearson r	P
Entorhinal	− 0.01	0.96	0.29	0.17
Parahippocampal	− 0.45	0.10	0.18	0.40
Amygdala	0.03	0.92	0.35	0.09
Lateral temporal	− 0.24	0.40	− 0.10	0.64
Prefrontal	− 0.04	0.88	− 0.28	0.19
PCC/precuneus	− 0.06	0.83	− 0.23	0.29
Anterior cingulate	0.14	0.63	0.02	0.93
Lateral parietal	− 0.13	0.65	− 0.26	0.22
Lateral occipital	− 0.02	0.96	− 0.32	0.12
Medial occipital	0.03	0.91	− 0.46	0.02*
Pericentral	0.09	0.77	− 0.12	0.58

Data are Pearson r and associated two-tailed P values obtained from separate univariate linear regression analyses in each group, uncorrected for multiple comparisons. Correlations between regional [¹¹C] PiB and [¹¹C]UCB-J DVR were assessed within 4 medial temporal structures and 8 neocortical ROIs. * denotes P < 0.05. Abbreviations: PCC posterior cingulate cortex, PiB Pittsburgh Compound B, SV2A synaptic vesicle glycoprotein 2A, DVR distribution volume ratio using a whole cerebellum reference region, ROI region of interest, aMCI amnestic mild cognitive impairment