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. 2021 Jan 6;40:9. doi: 10.1186/s13046-020-01819-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Lnc-GAN1 is downregulated in NSCLC tissues. a Lnc-GAN1 is significantly downregulated in 194 NSCLC tissues compared with 100 matched adjacent normal lung tissue detected by lncRNA microarray (*** P < 0.001). b lnc-GAN1 levels in 30 pairs NSCLC and adjacent tissues were measured by real-time qRT-PCR. lnc-GAN1 level is significantly lower in NSCLC tissues than in the paired adjacent normal lung tissues. (* P < 0.05). c lnc-GAN1 expression level is lower in lung adenocarcinomas (n = 483) than in the normal lung tissues (n = 347) obtained from TCGA (* P < 0.05). d lnc-GAN1 is highly expressed in NSCLC tumors less than 3 cm than in those larger than or equal to 3 cm (*** P < 0.001). e, f Kaplan-Meier survival analysis suggests that NSCLC patients with high lnc-GAN1 levels had better overall survival (OS) and disease-free survival (DFS) than those with low lnc-GAN1 expression