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. 2021 Jan 6;40:9. doi: 10.1186/s13046-020-01819-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Lnc-GAN1 repressed cell proliferation through cell cycle signaling pathway. a KEGG pathway analysis of differentially expressed genes that were generated by the SurePrint G3 Human Microarray analysis of A549-NC and A549-lnc-GAN1 stable cells indicates that cell cycle signaling pathway is involved in lnc-GAN1 inhibiting NSCLC progression. b Overexpressed lnc-GAN1 elevates PTEN protein and decreases Cyclin D1 and CDK4 proteins in A549 and H460 cells, while lnc-GAN1 downregulation has the opposite effects in H1299 and H1650 cells. c Molecular mechanism of lnc-GAN1