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. 2021 Jan 5;9:1. doi: 10.1186/s40478-020-01099-x

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — RNA sequencing reveals altered gene expression of each CNS cell-type in human precuneus with Alzheimer’s disease (AD) pathology. a Human brain samples were selected for analysis based on the Braak staing as follows: control brain (non-AD) defined as Braak stage (senile plaque: SP): 0–A, Braak stage (neurofibrillary tangle: NFT): 0–II; and AD brain defined as Braak stage (SP): C and Braak stage (NFT): III–IV. b Schematic overview of the gene expression analysis of the CNS cell-type markers in the precuneus of non-AD (n = 14) and AD (n = 11). c Expression of representative genes enriched in astrocytes, microglia, and oligodendrocytes in precuneus of AD brain with fold change. Downregulated genes (statistically significant, q < 0.05) are shown in red and bold