Table 3.
Multivariate analysis of all characteristics on overall survival
| Variable | pre-HR (95% CI) | P value | post-HR (95% CI) | P value | diff-HR (95% CI) | P value |
|---|---|---|---|---|---|---|
| Age | 1.049 (0.565, 1.948) | 0.879 | 0.569 (0.254, 1.272) | 0.169 | 0.556 (0.242, 1.277) | 0.166 |
| Tumor Location | 0.160* | 0.020* | 0.318* | |||
| Upper third | 1 | 1 | 1 | |||
| GEJ | 0.298 (0.048, 1.849) | 0.194 | 0.470 (0.060, 3.698) | 0.473 | 0.314 (0.025, 3.883) | 0.367 |
| Middle third | 0.512 (0.186, 1.406) | 0.194 | 0.108 (0.020, 0.586) | 0.010 | 0.192 (0.031, 1.205) | 0.078 |
| Lower third | 0.532 (0.222, 1.278) | 0.158 | 0.265 (0.083, 0.844) | 0.025 | 0.542 (0.163, 1.801) | 0.318 |
| Diffuse | 1.170 (0.420, 3.259) | 0.763 | 0.872 (0.261, 2.912) | 0.824 | 0.876 (0.216, 3.556) | 0.853 |
| Tumor Depth (cm) | 1.493 (0.738, 3.023) | 0.265 | 1.695 (0.615, 4.669) | 0.308 | 1.655 (0.610, 4.488) | 0.322 |
| ypT | 0.425* | 0.051* | 0.109* | |||
| 0 | 1 | 1 | 1 | |||
| 1–2 | 0.212 (0.016, 2.860) | 0.243 | 0.103 (0.005, 2.333) | 0.153 | 0.129 (0.006, 2.933) | 0.199 |
| 3–4 | 0.414 (0.022, 7.627) | 0.553 | 1.207 (0.020, 71.782) | 0.928 | 1.018 (0.019, 55.965) | 0.993 |
| ypN | 0.036* | 0.003* | 0.004* | |||
| 0 | 1 | 1 | 1 | |||
| 1 | 6.372 (1.280, 31.734) | 0.024 | 45.419 (6.213, 332.002) | 0.000 | 26.013 (3.647, 185.553) | 0.001 |
| 2 | 7.865 (1.399, 44.214) | 0.019 | 36.926 (4.488, 303.797) | 0.001 | 21.381 (2.539, 180.016) | 0.005 |
| 3 | 13.512 (2.217, 82.368) | 0.005 | 49.034 (5.063, 474.881) | 0.001 | 52.701 (5.358, 518.388) | 0.001 |
| ypTNM | 0.759* | 0.192* | 0.256* | |||
| I | 1 | 1 | 1 | |||
| II | 1.449 (0.209, 10.075) | 0.708 | 0.582 (0.031, 10.892) | 0.718 | 0.571 (0.028, 11.584) | 0.716 |
| III | 0.927 (0.059, 14.55) | 0.957 | 0.103 (0.002, 5.181) | 0.256 | 0.114 (0.002, 5.424) | 0.271 |
| Histological type | 0.583 (0.309, 1.097) | 0.094 | 1.234 (0.562, 2.710) | 0.600 | 1.168 (0.515, 2.648) | 0.710 |
| Lauren Classification | 1.774 (0.972, 3.238) | 0.062 | 0.919 (0.426, 1.982) | 0.830 | 1.022 (0.422, 2.476) | 0.961 |
| Grade of differentiation | 2.592 (1.074, 6.257) | 0.034 | 3.495 (0.980, 12.457) | 0.054 | 4.807 (1.345, 17.176) | 0.016 |
| VOLI | 1.623 (0.925, 2.849) | 0.091 | 4.532 (2.045, 10.043) | 0.000 | 2.529 (1.005, 6.364) | 0.049 |
| NI | 0.946 (0.543, 1.646) | 0.843 | 0.957 (0.501, 1.829) | 0.894 | 1.120 (0.544, 2.305) | 0.758 |
| Adjuvant therapy | 3.421 (1.488, 7.866) | 0.004 | 5.853 (1.919, 17.852) | 0.002 | 7.236 (2.419, 21.647) | 0.000 |
| CEA | 1.265 (0.712, 2.247) | 0.423 | 1.105 (0.511, 2.390) | 0.800 | 0.903 (0.399, 2.044) | 0.807 |
| CA199 | 0.984 (0.530, 1.829) | 0.960 | 1.570 (0.606, 4.066) | 0.353 | 1.032 (0.483, 2.206) | 0.936 |
| CA125 | 1.503 (0.821, 2.754) | 0.187 | 1.492 (0.774, 2.878) | 0.232 | 2.353 (1.068, 5.184) | 0.034 |
| CA724 | 2.177 (1.169, 4.056) | 0.014 | 2.349 (1.057, 5.220) | 0.036 | 1.238 (0.581, 2.638) | 0.581 |
VOLI Vascular or lymphatic invasion, NI Nervous invasion, GEJ Gastroesophageal junction; *P values from joint tests