Table 3.

Regression analysis of the association between drug addiction features and candidate SNPs of OPRM1 gene

SNP ID	Covariate	Regression coefficients B B vs Expected. B*		P-value**
rs648893	Age	0.42	1.53	< 0.0001
	Smoking	−1.27	0.28	< 0.0001
	Work	0.10	1.10	0.55
	Marital status	−1.34	0.26	< 0.0001
	GG	−0.28	0.75	0.33
	AG	0.11	1.11	0.44
	AA	reference
rs609148	Age	0.42	1.52	< 0.0001
	Smoking	−1.27	0.28	< 0.0001
	Work	0.08	1.09	0.61
	Marital status	−1.33	0.26	< 0.0001
	GG	0.30	1.35	0.27
	AG	0.29	1.33	0.31
	AA	reference
rs3823010	Age	0.42	1.52	< 0.0001
	Smoking	−1.28	0.27	< 0.0001
	Work	0.10	1.11	0.53
	Marital status	−1.34	0.26	< 0.0001
	GG	0.07	1.07	0.92
	AG	0.06	1.06	0.93
	AA	reference
rs1799971	Age	0.42	1.52	< 0.0001
	Smoking	−1.28	0.27	< 0.0001
	Work	0.11	1.12	0.50
	Marital status	−1.34	0.26	< 0.0001
	GG	0.73	2.08	0.23
	AG	0.47	1.61	0.01
	AA	reference
rs524731	Age	0.42	1.53	< 0.0001
	Smoking	−1.30	0.27	< 0.0001
	Work	0.06	1.07	0.62
	Marital status	−1.35	0.25	< 0.0001
	CC	−0.04	0.95	0.90
	CA	−0.06	0.93	0.87
	AA	reference
rs511435	Age	0.42	1.52	< 0.0001
	Smoking	−1.30	0.27	< 0.0001
	Work	0.08	1.08	0.69
	Marital status	− 1.33	0.26	< 0.0001
	CC	0.18	1.20	0.63
	CT	0.15	1.16	0.70
	TT	reference
rs1381376	Age	0.41	1.51	< 0.0001
	Smoking	−1.27	0.28	< 0.0001
	Work	0.11	1.11	0.53
	Marital status	−1.32	0.26	< 0.0001
	CC	0.33	1.39	0.65
	CT	0.16	1.18	0.82
	TT	reference
rs3778156	Age	0.44	1.55	< 0.0001
	Smoking	−1.26	0.28	< 0.0001
	Work	0.10	1.10	0.56
	Marital status	−1.37	0.25	< 0.0001
	GG	0.03	1.03	0.96
	AG	−0.19	0.82	0.31
	AA	reference
rs2075572	Age	0.42	1.524	< 0.0001
	Smoking	−1.26	0.283	< 0.0001
	Work	0.10	1.112	0.53
	Marital status	−1.34	0.262	< 0.0001
	CC	−0.18	0.833	0.34
	CG	−0.11	0.896	0.50
	GG	reference
0063rs548646	Age	0.43	1.54	< 0.0001
	Smoking	−1.29	0.27	< 0.0001
	Work	0.10	1.11	0.54
	Marital status	−1.31	0.26	< 0.0001
	CC	0.05	1.05	0.81
	CT	0.01	1.01	0.96
	TT	reference
rs671531	Age	0.42	1.52	< 0.0001
	Smoking	−1.25	0.28	< 0.0001
	Work	0.09	1.09	0.58
	Marital status	−1.34	0.26	< 0.0001
	GG	0.15	1.16	0.49
	AG	0.14	1.15	0.52
	AA	reference

* Beta coefficients

** P-Value < 0.05 is considered as significant