Table 5.

Regression analysis of the association between drug addiction features and candidate SNPs of OPRD1 gene

SNP ID	Covariate	Regression coefficients B B vs Expected. B*		P-value**
rs569356	Age	0.42	1.52	< 0.0001
	Smoking	−1.25	0.28	< 0.0001
	Work	0.11	1.12	0.50
	Marital status	−1.34	0.26	< 0.0001
	GG	0.50	1.65	0.59
	AG	−0.05	0.95	0.80
	AA	reference
rs1042114	Age	0.30	1.36	0.01
	Smoking	−1.28	0.27	< 0.0001
	Work	0.17	1.19	0.29
	Marital status	−0.96	0.38	< 0.0001
	GG	−0.27	0.75	0.72
	TG	0.01	1.01	0.95
	TT	reference
rs2236857	Age	0.30	1.35	0.01
	Smoking	−1.25	0.28	< 0.0001
	Work	0.16	1.18	0.32
	Marital status	−0.95	0.38	< 0.0001
	CC	−0.22	0.80	0.80
	TC	−0.25	0.77	0.77
	TT	reference
rs2236855	Age	0.31	1.36	0.01
	Smoking	−1.24	0.288	< 0.0001
	Work	0.17	1.19	0.29
	Marital status	−0.96	0.38	< 0.0001
	CC	0.27	1.31	1.31
	CA	−0.02	0.97	0.97
	AA	reference
rs2298896	Age	0.30	1.35	0.01
	Smoking	−1.26	0.28	< 0.0001
	Work	0.18	1.20	0.27
	Marital status	− 0.95	0.38	< 0.0001
	GG	−0.33	0.71	0.08
	TG	−0.26	0.77	0.09
	TT	reference
rs421300	Age	0.31	1.37	0.004
	Smoking	−1.24	0.28	< 0.0001
	Work	0.19	1.20	0.26
	Marital status	−0.97	0.37	< 0.0001
	GG	−0.25	0.77	0.19
	GA	−0.10	0.90	0.51
	AA	reference
rs529520	Age	0.31	1.37	0.004
	Smoking	−1.23	0.29	< 0.0001
	Work	0.18	1.20	0.27
	Marital status	−0.94	0.38	< 0.0001
	CC	0.23	1.27	0.20
	CA	0.15	1.16	0.32
	AA	reference
rs12749204	Age	0.29	1.34	0.01
	Smoking	−1.25	0.28	<0.0001
	Work	0.17	1.19	0.28
	Marital status	−0.96	0.38	<0.0001
	GG	− 0.25	0.77	0.37
	AG	−0.11	0.89	0.42
	AA	reference
rs2234918	Age	0.31	1.36	0.004
	Smoking	−1.27	0.28	<0.0001
	Work	0.19	1.21	0.25
	Marital status	−0.97	0.37	<0.0001
	CC	−0.13	0.87	0.50
	CT	−0.18	0.83	0.30
	TT	reference

* Beta coefficients

** P-Value < 0.05 is considered as significant