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. Author manuscript; available in PMC: 2021 Jan 6.
Published in final edited form as: Nat Rev Cancer. 2020 Apr 27;20(7):383–397. doi: 10.1038/s41568-020-0256-z

Fig. 2 |. Factors that influence the ability of oncoproteins to cause transformation.

Fig. 2 |

The presence of oncogenic mutations in a tissue can lead to its transformation. However, this dogmatic view appears to be the exception rather than the rule. This figure depicts some of the factors that are likely to contribute to the process of oncoprotein-mediated transformation, which are dependent either on the characteristics of the oncoprotein itself (intrinsic factors) or the microenvironment and macroenvironment (extrinsic factors). Some of these factors are at the crossroads of this binary classification. The exact combination of factors required to facilitate tissue transformation is unknown, but it is reasonable to expect that many are needed and each tissue would require a different combination.