Figure 4.

Diagnostic discordant case: left frontal GBM (case n. 6). (A, B) Sagittal and coronal T1 after contrast administration images showing location of tissue biopsies sampled at tumor central core, where CONVIVO® scan (C) disclosed «necrosis» (amorphous area with few cells and intermediate fluorescence background). (D) Definitive histology of the sample showing a small part of tumor tissue (black arrow), adjacent to amorphous material with only some “ghost” cells and vessels, consistent to necrosis and corresponding at the area analyzed by CONVIVO®. Taken together, these features set out the diagnosis of GBM. In this specific case, the discordant results for both tumor diagnosis and morphological categorization at central core were due to a larger field of observation with the optical microscope used at the permanent section examination.