Table 1.

Comparison between CONVIVO®, frozen section, and permanent section at central core.

CENTRAL CORE
DIAGNOSIS							MORPHOLOGICAL CATEGORIZATION
Pt. n°	CONVIVOANALYSIS	SAMPLE A1(FROZEN SECTION)	Concordance	CONVIVOANALYSIS	SAMPLE A2(PERMANENT SECTION)	Concordance	CONVIVOANALYSIS	SAMPLE A1(FROZEN SECTION)	Concordance	CONVIVOANALYSIS	SAMPLE A2(PERMANENT SECTION)	Concordance
1	High grade tumor—high cellularity	High grade glioma	+	High grade tumor—high cellularity	GBM (IV grade WHO 2016)	+/−	Tumor tissue Vascular proliferation	Tumor tissue Vascular proliferation	+ +	Tumor tissue Vascular proliferation	Tumor tissue Vascular proliferation necrosis	+ + −
2	Tumor tissue	Tumor tissue	+	Tumor tissue	GBM (IV grade WHO 2016)	+/−	Tumor tissue	Tumor tissue	+	Tumor tissue	Tumor tissue Necrosis Vascular proliferation	+ + −
3	High-density tumor tissue Presumable necrosis	GBM: large cells and necrosis	+/−	High-density tumor tissue Presumable necrosis	Giant cells GBM (IV Grade WHO 2016)	+/−	Tumor tissue Likely necrosis	Tumor tissue Necrosis	+ +	Tumor tissue Likely necrosis	Tumor tissue Necrosis Vascular proliferation	+ + −
4	Tumor with large cells Presumable necrosis	Giant cells GBM	+	Tumor with large cells Presumable necrosis	Giant cells GBM (IV Grade WHO 2016)	+	Tumor tissue Likely necrosis	Tumor tissue Necrosis Vascular proliferation	+ + -	Tumor tissue Likely necrosis	Tumor tissue Necrosis Vascular proliferation	+ + −
5	Tumor Mostly necrosis	GBM—Mostly necrosis	+/−	Tumor Mostly necrosis	GBM (IV grade WHO 2016)	+/−	Tumor tissue Necrosis	Tumor tissue Necrosis Vascular proliferation	+ + −	Tumor tissue Necrosis	Tumor tissue Necrosis	+ +
6	Necrosis	GBM—Necrosis Nervous tissue slightly infiltrated by tumor cells	−	Necrosis	GBM (IV grade WHO 2016)	−	Necrosis	Necrosis Tumor tissue	+ −	Necrosis	Necrosis Tumor tissue	+ −
7	High-density tumor tissue Pathological blood vessels	HGG Tumor tissue Pathological blood vessels	+	High-density tumor tissue Pathological blood vessels	GBM (IV grade WHO 2016)	+/−	Tumor tissue Vascular proliferation	Tumor tissue Vascular proliferation	+ +	Tumor tissue Vascular proliferation	Tumor tissue Necrosis	+ −
8	Necrosis	Necrosis	+	Necrosis	Necrosis	+	Necrosis	Necrosis	+	Necrosis	Necrosis	+
9	Infiltrated nervous tissue	GBM—Tumor tissue Necrosis	−	Infiltrated nervous tissue	GBM (IV grade WHO 2016)	−	Infiltrated tissue	Tumor tissue Necrosis	−	Infiltrated tissue	Tumor tissue Necrosis Vascular proliferation	−
10	Tumor Necrosis	GBM—Tumor tissue Necrosis	+/−	Tumor Necrosis	GBM (IV grade WHO 2016)	+/−	Tumor tissue Necrosis	Tumor tissue Necrosis Vascular proliferation	+ + −	Tumor tissue Necrosis	Tumor tissue Necrosis Vascular proliferation	+ + −
11	Tumor Necrosis	GBM—Tumor tissue Necrosis, partly fibrotic tissue	+/−	Tumor Necrosis	GBM (IV grade WHO 2016)	+/−	Tumor tissue Necrosis	Tumor tissue Necrosis	+ +	Tumor tissue Necrosis	Tumor tissue Necrosis Vascular proliferation	+ + −
12	Tumor—Necrosis Likely vascular proliferation	GBM Tumor tissue with small necrotic areas	+	Tumor—Necrosis Likely vascular proliferation	GBM (IV grade WHO 2016)	+/−	Tumor Necrosis Likely vascular proliferation	Tumor tissue Necrosis Infiltrated nervous tissue	+ + −	Necrosis Likely vascular proliferation	Tumor tissue Necrosis Vascular proliferation	− + +
13	Infiltrated nervous tissue	GBM Slightly infiltrated nervous tissue Necrosis Tumor tissue Vascular proliferation	−	Infiltrated nervous tissue	GBM (IV grade WHO 2016)	−	Infiltrated nervous tissue	Infiltrated nervous tissue Necrosis Tumor tissue Vascular proliferation	+ − − −	Infiltrated nervous tissue	Tumor tissue Necrosis Vascular proliferation	−
14	Tumor tissue Necrosis	GBM—Tumor tissue Mostly necrosis	+/−	Tumor tissue Necrosis	GBM (IV grade WHO 2016)	+/−	Tumor tissue Necrosis	Tumor tissue Necrosis	+ +	Tumor tissue Necrosis	Tumor tissue Necrosis	+ +
15	Tumor tissue Necrosis	GBM—Tumor tissue Necrosis	+/−	Tumor tissue Necrosis	GBM (IV grade WHO 2016)	+/−	Tumor tissue Necrosis	Tumor tissue Necrosis	+ +	Tumor tissue Necrosis	Tumor tissue Necrosis Vascular proliferation	+ + −