Table 2.
Comparison between CONVIVO®, frozen section, and permanent section at the tumor margin.
| TUMOR MARGINS | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DIAGNOSIS | MORPHOLOGICAL CATEGORIZATION | |||||||||||
| Pt. n° | CONVIVOANALYSIS | SAMPLE B1(FROZEN SECTION) | Concordance | CONVIVOANALYSIS | SAMPLE B2(PERMANENT SECTION) | Concordance | CONVIVOANALYSIS | SAMPLE B1(FROZEN SECTION) | Concordance | CONVIVOANALYSIS | SAMPLE B2(PERMANENT SECTION) | Concordance |
| 1 | Tumor | High-grade glioma | +/− | Tumor with blood | GBM (IV grade WHO 2016) |
+/− | Marginal infiltrated tissue | Tumor tissue | − | Infiltrated tissue | Tumor tissue Necrosis Vascular proliferation |
− |
| 2 | Infiltrated nervous tissue Blood |
Tumor (anaplastic glioma) Side with infiltrated nervous tissue Blood |
+ | Infiltrated nervous tissue Blood |
HGG | − | Marginal infiltrated tissue | Tumor tissue Infiltrated tissue |
− + |
Marginal infiltrated tissue | Tumor tissue with blood | − |
| 3 | Infiltrated nervous tissue High cellularity |
Nervous tissue infiltrated by tumor | + | Infiltrated nervous tissue | Giant cells GBM (IV Grade WHO 2016) |
− | Infiltrated tissue | Tumor tissue (mostly) Infiltrated tissue |
− + |
Infiltrated tissue | Tumor tissue Necrosis Vascular proliferation |
− |
| 4 | Tumor (not high cellularity) Presumable necrosis |
Giant cells GBM | +/− | Tumor (not high cellularity) Presumable necrosis |
Giant cells GBM (IV Grade WHO 2016) |
+/− | Infiltrated tissue Likely necrosis |
Tumor tissue Necrosis Vascular proliferation |
− + − |
Infiltrated tissue Likely necrosis |
Tumor tissue Necrosis Vascular proliferation |
− + − |
| 5 | Tumor necrosis |
GBM | +/− | Tumor necrosis |
GBM (IV grade WHO 2016) |
+/− | Tumor tissue Necrosis |
Tumor tissue Vascular proliferation |
+ − |
Tumor tissue Necrosis |
Tumor tissue Necrosis |
+ + |
| 6 | Infiltrated nervous tissue at borders | GBM Micronecrosis |
− | Infiltrated nervous tissue at borders | Nervous tissue infiltrated by GBM (IV grade WHO 2016) |
+ | Infiltrated tissue | Tumor tissue Necrosis Vascular proliferation |
− | Infiltrated tissue | Infiltrated tissue | + |
| 7 | Infiltrated nervous tissue at borders Blood |
HGG Tumor tissue Infiltrated tissue |
+/− | Infiltrated nervous tissue at borders Blood |
HGG | +/− | Infiltrated tissue | Tumor tissue Infiltrated tissue |
− + |
Infiltrated tissue | Tumor tissue Infiltrated tissue |
− + |
| 8 | Tumor tissue on a side Infiltrated nervous tissue and borders on the other side |
Tumor tissue on a side Infiltrated nervous tissue and borders on the other side |
+ | Infiltrated nervous tissue | GBM (IV grade WHO 2016) |
− | Tumor tissue Infiltrated tissue |
Tumor tissue Infiltrated tissue |
+ + |
Infiltrated tissue | Tumor tissue Necrosis Vascular proliferation |
− |
| 9 | Highly infiltrated nervous tissue | GBM—Tumor tissue Necrosis |
− | Highly infiltrated nervous tissue | Mostly necrotic tissue with marginal GBM | − | Infiltrated tissue | Tumor tissue Infiltrated tissue |
− | Infiltrated tissue | Tumor tissue Necrosis |
− |
| 10 | Tumor tissue Infiltrated nervous tissue |
GBM—Tumor tissue and necrosis | +/− | Tumor tissue Infiltrated nervous tissue |
GBM (IV grade WHO 2016) |
+/− | Tumor tissue Infiltrated tissue |
Tumor tissue Necrosis Vascular proliferation |
+ − − |
Tumor tissue Infiltrated tissue |
Tumor tissue Necrosis Vascular proliferation |
+ − − |
| 11 | Tumor tissue Infiltrated nervous tissue |
GBM—Tumor and necrosis Side with infiltrated nervous tissue |
+/− | Tumor tissue Infiltrated nervous tissue |
GBM (IV grade WHO 2016) |
+/− | Tumor tissue Infiltrated tissue |
Tumor tissue Necrosis Infiltrated nervous tissue |
+ − |
Tumor tissue Infiltrated tissue |
Tumor tissue Necrosis Infiltrated nervous tissue |
+ − + |
| 12 | Tumor tissue Infiltrated nervous tissue |
GBM Tumor tissue and infiltrated tissue |
+/− | Tumor Infiltrated nervous tissue |
GBM (IV grade WHO 2016) |
+/− | Tumor tissue Infiltrated tissue |
Tumor tissue Infiltrated tissue |
+ + |
Tumor tissue Infiltrated nervous tissue |
Tumor tissue Infiltrated tissue |
+ + |
| 13 | Infiltrated nervous tissue Mostly blood |
GBM: slightly infiltrated nervous tissue Tumor tissue: vascular proliferation and blood |
− | Infiltrated nervous tissue Mostly blood |
GBM (IV grade WHO 2016), but mostly blood |
− | Infiltrated nervous tissue Blood |
Infiltrated nervous tissue Tumor tissue Vascular proliferation Blood |
+ − − |
Infiltrated nervous tissue Blood |
Tumor tissue Necrosis Vascular proliferation |
− + − |
| 14 | Tumor tissue | GBM Tumor tissue Necrosis |
+/− | Tumor tissue | GBM (IV grade WHO 2016) |
+/− | Tumor tissue | Tumor tissue Necrosis |
+ − |
Tumor tissue | Tumor tissue Necrosis Vascular proliferation |
+ − − |
| 15 | Infiltrated nervous tissue Tumor tissue |
Infiltrated nervous tissue Tumor tissue |
+ | Infiltrated nervous tissue Tumor tissue |
GBM (IV grade WHO 2016) |
+/− | Infiltrated nervous tissue Tumor tissue |
HGG—Tumor (80%) Infiltrated nervous tissue (20%) |
+ + |
Infiltrated nervous tissue Tumor tissue |
Tumor tissue Necrosis Vascular proliferation |
+ − − |