Table 3.

Multivariate survival analysis for MAHGED1 in TCGA-LGG dataset.

	OS			DSS			DFI			PFI
	HR	95%CI	p value	HR	95%CI	p value	HR	95%CI	p value	HR	95%CI	p value
MAGED1 expression	1.165	0.768–1.765	0.471	1.277	0.821–1.986	0.277	1.940	0.662–5.681	0.226	1.083	0.792–1.481	0.616
Histology
OA vs. O (Ref.)	1.222	0.672–2.220	0.51	1.253	0.657–2.390	0.492	0.331	0.070–1.565	0.163	0.766	0.479–1.224	0.265
A vs. O (Ref.)	1.143	0.643–2.031	0.647	1.325	0.720–2.436	0.365	0.593	0.170–2.070	0.413	1.018	0.663–1.565	0.932
Grade
III vs. II (Ref.)	2.022	1.278–3.198	0.003*	1.982	1.213–3.239	0.006*	0.501	0.189–1.326	0.165	1.049	0.748–1.471	0.778
IDH status
IDH MUT vs. WT (Ref.)	0.255	0.132–0.490	0*	0.221	0.111–0.439	0*	0.162	0.027–0.950	0.044*	0.221	0.134–0.366	0*
1p/19q Co-deletion status
Present vs. Absent (Ref.)	0.538	0.280–1.035	0.064	0.594	0.293–1.207	0.15	0.269	0.064–1.122	0.072	0.568	0.349–0.925	0.023*
MGMT promoter methylation status
Present vs. Absent (Ref.)	1.113	0.621–1.992	0.718	1.094	0.602–1.987	0.767	3.810	0.550–26.353	0.175	1.259	0.797–1.991	0.323
Age (increasing years)	1.054	1.036–1.072	0*	1.052	1.033–1.072	0*	1.040	0.992–1.090	0.099	1.021	1.008–1.034	0.001*
Gender
Female vs. Male (Ref.)	0.847	0.563–1.274	0.426	0.815	0.528–1.256	0.355	1.217	0.434–3.413	0.708	1.132	0.830–1.543	0.431

OS, overall survival; DSS, disease specific survival; DFI, disease free interval; PFI, progression free interval; HR, hazard ratio; CI, confidence interval; O, oligodendroglioma; OA, oligoastrocytoma; A, astrocytoma; WT, wild type; MUT, mutant, MGMT; O-6-methylguanine-DNA methyltransferase. * indicates p < 0.05.