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Percentage change from baseline for peripheral blood samples taken on day 28 of cycle 1 and assessed for pSTAT3, using plasma inhibitory assay.
| Patient ID | Ruxolitinib Dose Cohort, mg | K562 cells | KU812 cells | |
|---|---|---|---|---|
| pSTAT3 (Ser727), % change | pSTAT5 (Tyr694), % change | pSTAT3 (Tyr705), % change | ||
| 7 | 10 | +12 | −55 | −4 |
| 9 | 15 | +12 | −14 | −4 |
| 10 | 15 | +12 | −62 | −7 |
| 11 | 15 | +12 | −23 | −12 |
