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High-frequency ultrasound study showed significant increases of skin thickness and skin density after 18 months of intradermal injections of AFU in the nasolabial folds (A, B) and AFFL in crow’s feet (C, D). Panel A: Day 0, nasolabial folds, Subject No. 10. Panel B: Day 540, nasolabial folds, Subject No. 10. Panel C: Day 0, crow’s feet, Subject No. 28. Panel D: Day 540, crow’s feet, Subject No. 28.
